Mec1 regulates RAD9
| Mec1 upregulates RAD9 binding Confidence: High |
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Our results suggest that Mec1 promotes association of Rad9 with sites of DNA damage, thereby leading to full phosphorylation of Rad9 and its interaction with Rad53.
(PubMed 15060150 - Visualize document)
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| Mec1 upregulates RAD9 expression Confidence: Average |
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Mec1, in collaboration with the clamp and the clamp loader, activates the downstream kinases Rad53 and Chk1 with the assistance of the checkpoint mediator Rad9 (Sanchez et al, 1996; Sun et al, 1996; Sweeney et al, 2005).
(PubMed Central 2532783 - Visualize document)
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| Mec1 regulates RAD9 Confidence: Average |
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Selecting the target RAD9, the web application visualises all event structures expressing regulation of RAD9 by Mec1 (Figure 4).
(PubMed Central 3375141 - Visualize document)
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| Mec1 upregulates RAD9 Confidence: Low |
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These data suggest, first, that the checkpoint sliding clamp regulates and/or recruits some nucleases for degradation, and, second, that Mec1 activates Rad9 to activate Rad53 to inhibit degradation.
(PubMed 15020465 - Visualize document)
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Mec1 then activates a mediator kinase; either Mrc1 at stalled replication forks, or Rad9 at damaged sites.
(PubMed Central 3002893 - Visualize document)
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Here we show that Mec1 controls the Rad9 accumulation at double-strand breaks (DSBs).
(PubMed 15060150 - Visualize document)
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Similar to 53BP1, Rad9 is activated by the ATM/ATR homologues Tel1/Mec1 and associates with the Chk2 homologue Rad53 [98]-[100].
(PubMed Central 2811157 - Visualize document)
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| Mec1 binding upregulates RAD9 binding Confidence: Low |
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Our data suggest that Rad9's tandem BRCT domain mediates Rad9 oligomerization via its interaction with its own Mec1/Tel1-phosphorylated SQ/TQ cluster domain (SCD).
(PubMed 19187758 - Visualize document)
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| Mec1 upregulates RAD9 phosphorylation Confidence: Low |
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Rad9 phosphorylation, mediated by Mec1, is an early event in the signal transduction cascade and this modification in G1 is mainly influenced by histone H3 methylation [22], [33], [60], [62].
(PubMed Central 2916856 - Visualize document)
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Dpb11 is held in proximity to damaged DNA through its interaction with phosphorylated 9-1-1 complex, leading to Mec1-dependent Rad9 phosphorylation.
(PubMed Central 2916856 - Visualize document)
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DNA damage induces Mec1 kinase-dependent phosphorylation of Rad9 and Rad53 (36-38).
(PubMed Central 3077650 - Visualize document)
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It is thought that Mec1-dependent phosphorylation of Rad9 recruits and catalyses Rad53 activation (Gilbert et al, 2001; Sweeney et al, 2005).
(PubMed Central 2328446 - Visualize document)
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Our data suggest that Dpb11 is held in proximity to damaged DNA through an interaction with the phosphorylated 9-1-1 complex, leading to Mec1-dependent phosphorylation of Rad9.
(PubMed 18541674 - Visualize document)
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