TGF-beta1 and PGD2 have a common regulator IL-1beta

TGF-beta1 is regulated by IL-1beta
IL-1beta upregulates TGF-beta1 catabolism
Positive_regulation(C: IL-1beta, T: Protein_catabolism(T: TGF-beta1))
Confidence: High
Interleukin-1beta (IL-1beta), a key-cytokine in osteoarthritis, impairs TGFbeta signaling through TbetaRII down-regulation by increasing its degradation. Described in 2 sentences
IL-1beta upregulates TGF-beta1 localization
Positive_regulation(C: IL-1beta, T: Localization(T: TGF-beta1))
Confidence: High
IL-6 as well as IL-1beta enhanced TGF-beta1 secretion from PSCs. Described in 9 sentences
IL-1beta upregulates TGF-beta1 expression
Positive_regulation(C: IL-1beta, T: Gene_expression(T: TGF-beta1))
Confidence: High
CONCLUSIONS: Diltiazem suppressed collagen synthesis of human PMCs and inhibited IL-1beta-induced TGF-beta1 production on human PMCs. Described in 34 sentences
IL-1beta upregulates binding of AP4 and TGF-beta1
Positive_regulation(C: IL-1beta, T: Binding(T: AP4, T: TGF-beta1))
Confidence: High
CONCLUSION: IL-1beta induces an increase of TGFbeta1 in articular chondrocytes through activation of AP-4 and AP-1 binding to the TGFbeta1 gene promoter. Described in 1 sentence
IL-1beta upregulates binding of c-jun and TGF-beta1
Positive_regulation(C: IL-1beta, T: Binding(T: TGF-beta1, T: c-jun))
Confidence: High
CONCLUSION: IL-1beta induces an increase of TGFbeta1 in articular chondrocytes through activation of AP-4 and AP-1 binding to the TGFbeta1 gene promoter. Described in 1 sentence
IL-1beta regulates binding of IL-2 and TGF-beta1
Regulation(C: IL-1beta, T: Binding(T: IL-2, T: TGF-beta1))
Confidence: High
Other cytokines (IL-1, IL-3, IL-4, IL-5, TNF, LT, IFN-gamma, and TGF-beta) had no effect on IL-2 binding, suggesting that IL-6 may mediate the enhanced expression of HIL-2-R. Described in 1 sentence
IL-1beta upregulates TGF-beta1 transcription
Positive_regulation(C: IL-1beta, T: Transcription(T: TGF-beta1))
Confidence: High
NF-kappaB and activator protein 1 response elements and the role of histone modifications in IL-1beta-induced TGF-beta1 gene transcription. Described in 5 sentences
IL-1beta binding upregulates TGF-beta1 localization
Positive_regulation(C: Binding(T: IL-1beta), T: Localization(T: TGF-beta1))
Confidence: Average
These results demonstrate that the interaction of D-glucose and IL-1 beta lead to secretion of TGF-beta 1 by HPTC. Described in 1 sentence
IL-1beta upregulates TGF-beta1
Positive_regulation(C: IL-1beta, T: TGF-beta1)
Confidence: Average
In PANC-1 cells, IL-1beta and TNF-alpha induced a rapid activation of nuclear factor (NF)-kappaB, and TGF-beta1 enhanced this activation slightly. Described in 32 sentences
IL-1beta downregulates TGF-beta1 localization
Negative_regulation(C: IL-1beta, T: Localization(T: TGF-beta1))
Confidence: Low
Inhibition of TGF-beta(1) activity secreted from PSCs by TGF-beta(1)-neutralizing antibody attenuated IL-1beta secretion from PSCs. Described in 2 sentences
IL-1beta regulates TGF-beta1 expression
Regulation(C: IL-1beta, T: Gene_expression(T: TGF-beta1))
Confidence: Low
IL-1beta acts directly on T cells and affects Foxp3 and TGF-beta1 expression in them in a concentration dependent manner Described in 8 sentences
IL-1beta regulates TGF-beta1 localization
Regulation(C: IL-1beta, T: Localization(T: TGF-beta1))
Confidence: Low
The question of whether tumor necrosis factor alpha (TNF-alpha) and/or interleukin 1 beta (IL-1 beta) regulate the release of TGF-beta1 was investigated by incubation of adipose tissue explants with a soluble human TNF-alpha receptor (etanercept) and a neutralizing antihuman IL-1 beta antibody. Described in 4 sentences
Upregulation of IL-1beta upregulates TGF-beta1 localization
Positive_regulation(C: Positive_regulation(T: IL-1beta), T: Localization(T: TGF-beta1))
Confidence: Low
Secretion of IL-6, IL-8, and TNF-alpha, but not TGF-beta1, was increased by IL-1beta stimulation. Described in 1 sentence
IL-1beta downregulates TGF-beta1 expression
Negative_regulation(C: IL-1beta, T: Gene_expression(T: TGF-beta1))
Confidence: Very low
These observations indicated that IL-1beta and IL-12 can directly act on T cells upon activation and modulate Foxp3+ and TGF-beta1 expression. Described in 9 sentences
IL-1beta downregulates TGF-beta1
Negative_regulation(C: IL-1beta, T: TGF-beta1)
Confidence: Very low
IL-1beta and its downstream mediator TAK1 inhibit SMAD3-mediated TGFbeta target gene activation, whereas SMAD3 nuclear translocation and DNA binding in response to TGFbeta are not affected. Described in 11 sentences
IL-1beta regulates TGF-beta1
Regulation(C: IL-1beta, T: TGF-beta1)
Confidence: Very low
CONCLUSION: In summary, IL-1 has a biphasic effect on PTC TGF beta signalling, with early NF-kappaB-mediated inhibition and delayed sensitization via an autocrine IL-6 loop. Described in 10 sentences
IL-1beta expression downregulates TGF-beta1 expression
Negative_regulation(C: Gene_expression(T: IL-1beta), T: Gene_expression(T: TGF-beta1))
Confidence: Very low
Overexpression of TGF-beta1 or IL-1beta increased activated microglia and reduced Abeta load in the brains of AD mouse models [24,27]. Described in 1 sentence
IL-1beta binding upregulates TGF-beta1
Positive_regulation(C: Binding(T: IL-1beta), T: TGF-beta1)
Confidence: Very low
Moreover, IL-1beta has been shown to increase TGF-beta1 in articular chondrocytes through the activation of AP-4 and AP-1 binding to the TGF-beta1 gene promoter [72]. Described in 1 sentence
IL-1beta regulates binding of TGF-beta1 and IL-1beta
Regulation(C: IL-1beta, T: Binding(T: IL-1beta, T: TGF-beta1))
Confidence: Very low
Effects of IL-1beta alone or in combination with TGF-beta1 on EMT Described in 1 sentence
Upregulation of TGF-beta1 by IL-1beta is upregulated by upregulation of IL-1beta
Positive_regulation(C: Positive_regulation(T: IL-1beta), T: Positive_regulation(C: IL-1beta, T: TGF-beta1))
Confidence: Very low
Since substantial cross-talk between pro-inflammatory cytokines IL-1beta, TNF-alpha, IL-6, and IL-17 is essential to induce joint destruction in RA,1 IL-1beta and TNF-alpha promote IL-6 and tumor growth factor-beta (TGF-beta) driven process of Th17 cell commitment and IL-17 production.73 Th17 cell polarization further induces IL-1beta, TNF-alpha, IL-6, IL-8, and IL-17 production (Figure 1).74-77 Numerous studies have also demonstrated the critical role of B-cells in RA pathogenesis. Described in 1 sentence
Upregulation of TGF-beta1 by TNF-alpha is upregulated by upregulation of IL-1beta
Positive_regulation(C: Positive_regulation(T: IL-1beta), T: Positive_regulation(C: TNF-alpha, T: TGF-beta1))
Confidence: Very low
Since substantial cross-talk between pro-inflammatory cytokines IL-1beta, TNF-alpha, IL-6, and IL-17 is essential to induce joint destruction in RA,1 IL-1beta and TNF-alpha promote IL-6 and tumor growth factor-beta (TGF-beta) driven process of Th17 cell commitment and IL-17 production.73 Th17 cell polarization further induces IL-1beta, TNF-alpha, IL-6, IL-8, and IL-17 production (Figure 1).74-77 Numerous studies have also demonstrated the critical role of B-cells in RA pathogenesis. Described in 1 sentence
PGD2 is regulated by IL-1beta
IL-1beta upregulates PGD2 transcription
Positive_regulation(C: IL-1beta, T: Transcription(T: PGD2))
Confidence: High
The interleukin-1-beta (IL-1beta)-induced upregulation of lipocalin-type prostaglandin D synthase (L-PGDS) mRNA expression requires de novo protein synthesis. Described in 2 sentences
IL-1beta upregulates PGD2
Positive_regulation(C: IL-1beta, T: PGD2)
Confidence: Average
These results suggest that the activation of JNK and p38 MAPK as well as NF-kappaB is essential to the induction of L-PGDS by IL-1beta in chondrocytes. Described in 3 sentences
IL-1beta regulates PGD2 expression
Regulation(C: IL-1beta, T: Gene_expression(T: PGD2))
Confidence: Low
Effect of interleukin-1-beta (IL-1beta) on lipocalin-type prostaglandin D synthase (L-PGDS) expression in osteoarthritis chondrocytes. Described in 3 sentences
All interactions mentioned for the specific gene symbol in text. The results are not restricted to any specific organism.
All interactions for genes that have these gene symbols as official name or synonym. The results are restricted to specific organisms and synonyms are taken into account.
All interactions for families that contain genes with these gene symbols as official name or synonym. The results group interologs and regulogs together, and synonyms are taken into account for each gene in the gene family.
All interactions mentioned between these specific gene symbols in text. The results are not restricted to any specific organism.
All interactions between genes that have these gene symbols as official name or synonym. The results are restricted to specific organisms and synonyms are taken into account.
All interactions between families that contain genes with these gene symbols as official name or synonym. The results group interologs and regulogs together, and synonyms are taken into account for each gene in the gene family.
We recommend the latest versions of Google Chrome or Mozilla Firefox browsers for the best visualization experience. Internet Explorer versions 9 and 10 have been tested as well and should show the visualization correctly. However, older Internet Explorer versions are not capable of showing the graphics format used in these visualizations.